Following the Extra Preliminary and the Preliminary Rounds, this tie sees both teams getting underway in this competition for the first time this season.
The two have already met this term, when Harlow Town travelled to the south coast on the opening day of the league campaign, returning with a 4-2 loss.
The winners of this tie will received £3,250 in prize money, and a place in the Second Round Qualifying.
Kick off will be at 3pm on Saturday 27th October.